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Additionally, prolyl hydroxylase domain (PHD) inhibitors, such as the clinical drug Roxadustat (FG-4592), are capable of treating a variety of recalcitrant anaemiaincluding refractory anaemia, inflammatory anaemias, and chemotherapy-associated anaemiasby activating the HIF-2 axis [100]

Some evidence suggests that in AD, dysregulation of tight junction proteins, increased matrix metalloproteinase signaling, and degeneration and loss of pericytes may all contribute to BBB leakage, leading to the accumulation of numerous blood-derived neurotoxic proteins in the brain, causing neuroinflammation and oxidative stress