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This breaks down nitric oxide, which is released by the endothelium, and is important for helping blood vessels to dilate and for protecting against inflammation and clogging of the arteries. The researchers say the main toxic chemicals in e-cigarette vapor include formaldehyde and acrolein, as well as traces of chemicals called transition metals and volatile organic compounds (VOCs), all of which are known to damage cells

As their name suggests, these receptors are also sensitive to nicotine