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As previously noted, the lifetime risk curves for alcohol were modeled for people who consume 0 to 5 standard drinks, these health loss or harms related to alcohol use would surpass those associated with tobacco use

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(1) the metabolism of estrogen to genotoxic, mutagenic carcinogens, (2) the stimulation of tissue growth, and (3) the repression of phase II detoxification enzymes that metabolize ROS leading to increased oxidative DNA damage