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Data about tobacco smoking and alcohol consumption ( Figure 2 :++) indicated that are still the most prominent causes of cancer worldwide and are considered significant for OCSCC occurrence, and, as evidenced by studies published in the recent years, the comparison of the proportion of individuals reporting tobacco and alcohol consumption showed that these habits were more prevalent in the older group (48.4% and 45.8%, respectively) than in the younger group (39.5% and 30.9%, respectively)

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There also appears to be a genetic element to all this variations in the CNR1 gene (which encodes for the expression of CB-receptors) are associated with variations in susceptibility to nicotine dependence

But this confusing picture nonetheless shows startlingly unequal outcomes