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Chapter One: The global smoking epidemic and the role of tobacco harm reduction Chapter Two: The evidence for tobacco harm reduction Chapter Three: Global progress in tobacco harm reduction Chapter Four: Global regulation and control Chapter Five: The challenges to tobacco harm reduction Chapter Six: Conclusions Regional and national insights considers the status of tobacco use and THR at the regional or national level

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FJ, HA and MB appraised the methodological quality of the studies independently, using the McGill Mixed-Methods Appraisal Tool (MMA) 18