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Increased oxidative stress due to smoking contributes to atherosclerosis by inducing cell proliferation, cell hypertrophy, and apoptosis, either directly through vascular endothelial damage or through activation of various intracellular signaling pathways

Researchers recruited 1,941 regular cigarette smokers and 3,758 menthol smokers to compare each group's overall health condition over the course of 18 months

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Although the pro-THR community acknowledges that this product substitution also benefits those non-users surrounding the users of the new product, the issue remains of secondary importance for most, a loss of concern that aids the efforts of the orthodoxy to falsely regard passive vaping as too close in harms to passive smoking, thus arguing the need to apply same smoke-free policies to vaping