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Additionally, the APOE-4 allele is the strongest genetic risk factor for both early- and late-onset AD, contributing to increased amyloid deposition and disease progression (Kim et al., 2009)

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There are few known mammalian lipoylated proteins and most of them are concentrated in tricarboxylic acid (TCA) cycle, while cells with active mitochondrial respiration show elevated lipoylated proteins (Tsvetkov et al., 2022

On the other hand, there is no doubt that in rat models of cocaine use disorder (CUD), NAC did not change cocaine reward, but effectively reduced escalation of drug intake, cocaine-seeking, and reinstatement behaviors [8, 10, 14, 19, 21, 50,51,52,53,54,55,56,57] (Table 1)