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No, that's not possible

When inflammation occurs, multiple inflammatory signaling pathways are activated, such as p38 MAP kinase (p38 MAPK), phosphatidylinositol-3-kinase (PI3K), and janus kinase/signal transducer and activator of transcription (JAK/STAT) [103]

Investigative Med

The addictive nature of nicotine is due to its ability to rapidly cross the blood-brain barrier and induce the release of dopamine, creating pleasurable sensations