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The toxicity of cadmium is characterized by a reduction in reduced glutathione (GSH), binding of sulfhydryl groups with proteins, and stimulation of the production of reactive oxygen species (ROS) such as superoxide ion, hydrogen peroxide, and hydroxyl radicals (source: National Center For Biotechnology Information)

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Additionally, PPAR expression was decreased in DC and significantly upregulated in TC THP1 model upon CS exposure, suggesting an adaptive response to lipid dysregulation (Supplementary Fig