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Rats exposed to DDT did not have any unusual changes to their fat cells or body size and neither did their offspring, yet surprisingly, more than 50% of the third generation of rats whose grandparents were exposed to DDT were obese.[25] Levels of exposure for the rats were not high and was far less than the lowest observed adverse effect level for DDT in humans, yet it still had a marked transgenerational effect

Cigarette smoke exposure followed by DSS-induced colitis resulted in significantly greater weight loss, higher clinical scores, shorter colon lengths, and more severe pathological and endoscopic assessments in Gpr15 / mice than in Gpr15 +/+ mice (Fig