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Moreover, SMG secretory cells produce a MUC5B -dominated mucus that requires less post-translational processing and glycosylation than surface epithelial mucus production, consistent with recent studies finding that mucus produced from the SMGs has distinct physical properties from that of surface epithelia 36,37

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Even minimal smoking of 1-2 cigarettes per day raised the risk by 31%, with the risk steadily climbing to 53% higher for those smoking 20 or more cigarettes daily

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