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[83,89] Briefly, the reduced quantities of transported O2 and the decreased O2 supply to and uptake from the active tissues, combined with the binding of myoglobin by CO, significantly decrease maximal oxygen uptake (VO2max) reducing the functional capacity and the performance of the circulatory system ( Figure 2 )

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At the time, the harmfulness of cigarettes was not properly recognized even in the medical community, so it was common for doctors to smoke in the examination room while treating patients

In April, Lorillard purchased Blu (here), and Craver reports that the company has invested $40 million in a marketing campaign