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Clinically Significant Drug Interactions with Antidepressants in the Elderly

A priori power analyses were conducted using G*Power v3.1.9.2, determining that a sample size of 40 would adequately detect a significant small-to-medium effect ( p 2 = .05, = 0.05, within-subject correlation = 0.5) of the 2 2 between-within subject interaction on a continuous outcome with 80% power

The final study population comprised 178 never smokers, 242 cigarette smokers, and 237 HTP smokers (n=657) (final response rate: 82.1%) (Figure 1)

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