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The rate of current alcohol consumption increases with increasing age according to the 2024 National Survey on Drug Use and Health (NSDUH) from 1.3% among 12-13 year olds to nearly 5% among 14-15 years to 13% at ages 16-17, and more than doubling among 18-20 year olds (27%)

WHO Report on the Global Tobacco Epidemic, 2023

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38 Furthermore, studies in nicotine-dependent rats show that conditioned stimuli associated with nicotine withdrawal increase the magnitude of withdrawal through an elevation of the brains reward threshold