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8 Surprising Facts About Heartburn Is Smoking Making My Acid Reflux Worse? Tampa Bay Reflux Center CAN SMOKING CAUSE GASTROESOPHAGEAL REFLUX DISEASE (GERD)? ISDE Cigarette smoke contains thousands of chemicals, many of which are toxic and harmful to the human body. Here's a detailed breakdown of some of the most dangerous constituents and their effects: 1.
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