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In vivo animal experiments showed that daily administration of NNMTi for 28 days to dietinduced obese (DIO) mice significantly upregulated the expression of lipolysisrelated genes (such as ATGL and HSL) and downregulated lipogenesisrelated genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis

The mean age of the enrolled participants was 53.8 (SD = 9)

The injection can be given in the abdomen, thigh, or upper arm, with rotation of injection sites recommended to prevent lipodystrophy

Healthcare professionals should maintain vigilance regarding these intersecting risk factors when managing patients on GLP-1 receptor agonists