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The molecular pathophysiology of depression and the new therapeutics

Under normal conditions, extracellular iron bounding to transferrin to form a complex is mediated by transferrin receptor 1 (TfR1) on the cell membrane into the intracellular compartment, where it is converted to ferrous ions by ferric reductase and subsequently stored in the intracellular unstable iron pool via the divalent metal transporter protein divalent metal transporter 1 (DMT1), and the excess iron ions are stored as inert iron in ferritin in the cell, maintaining intracellular iron homeostasis (Masaldan et al., 2018