Propargyl-Acetyl-Val-Cit-PAB(m-PEG8)-MMAE fluorescent Product Name: 5(6)-ROX azide Synonyms:

Product Name: 5(6)-ROX azide Synonyms: 5-(and -6)-Carboxy-X-rhodamine Azide CAS Number: N/A Molecular Formula: C36H36N6O4 Molecular Weight: 616

and a brief treatment with 100 mM MESNA results in a near-complete loss of fluorescence

Identification of Potent

Product Name Thalidomide-5'-piperazine-C2-piperazine HCl Synonyms CAS Number n/a Related CAS Molecular Formula C23H33Cl3N6O4 Molecular Weight 563

Propargyl-Acetyl-Val-Cit-PAB(m-PEG8)-MMAE fluorescent Product Name: 5(6)-ROX azide Synonyms:SOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing