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PI3KAKTmTOR Consistent with their role in apoptosis suppression, cell proliferation, metabolism and anabolic reactions, the interconnected PI3KAKT and mTOR pathways are hyperactivated in almost 40% of all human cancers

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ROS initiates increase of P2X7 expression on the mitochondrial membrane and activity of Complex I, hence increasing mitochondrial polarization, which leads to an elevation of a cascade of unfavorable processes: depolarization of the mitochondrial membrane, calcium overload, and release of cytochrome c , which ultimately leads to cell death by apoptosis way