Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan fluorescent BC-N3 is a CLIP-tag substrate

BC-N3 is a CLIP-tag substrate containg an azide group for click chemistry applications

Product Name DOTA-tris(t-Bu)ester-C4-azide Synonyms CAS Number n/a Related CAS Molecular Formula C32H60N8O7 Molecular Weight 668

635 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NC(CCCCN)C(O)=O)=[N+](C)C)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Product Name 1-bromo-4-(methoxy-d3)benzene Synonyms 1-bromo-4-(²H3)methoxybenzene CAS Number 100835-59-4 Related CAS Molecular Formula C7H7BrO Molecular Weight 190

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan fluorescent BC-N3 is a CLIP-tag substrateSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by