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doi:10.1016/j.otohns.2008.11.021 Yen TL, Driscoll CL, Lalwani AK

[99] From these data, SOD1 mutants are typically segregated into two broad groups: metalbinding region (MBR) mutants which exhibit impaired metal binding and diminished catalytic rates, and wildtypelike (WTL) mutants which possess more similar metalbinding affinities, structural conformations and enzymatic activities to wildtype SOD1 protein (Table 2

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Elevated lactate is also a biomarker assessed in the diagnostic process for individuals with primary mitochondrial diseases and thus is worth highlighting and conducting further studies of lactate-producing bacteria in this population (Schapira, 2006)