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To decipher the impact of the ligands on the proteins active site, we focused on the region known to play a crucial role in substrate binding

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*Correspondence: Yong-Yu Yang, [email protected] This article was submitted to Diabetes: Molecular Mechanisms, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers