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At the same time, its level can mark the neuroprotection/neurodegeneration balance (Depeint et al., 2006

Excessive intake of trans fatty acid accelerates atherosclerosis through promoting inflammation and oxidative stress in a mouse model of hyperlipidemia

It has three major domains: a) variable N-terminal domain (421 amino acids), b) central DNA binding domain (65 amino acids), and c) C-terminal domain (250 amino acids)