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- Reduces hyperpigmentation: Diminishes dark patches and discoloration over time

These studies build up the possibility of melatonin being able to reverse the underling BMAL1 deficiency-induced ferroptosis in post-COVID-19 aging and neurodegeneration

They found that in NRF-2/PGC-1 dKO mice, there is elevation of various autophagosomal markers (p62/SQSTM1, Beclin-1 and LC3B) along with the increased levels of microglia marker, Iba1 and accumulation of oxidative stress markers (4-HNE) and endoplasmic reticulum stress markers (GRP78 and ATF4

Additionally, insulin resistance can result in aberrant hepatic glycogen metabolism ( 2.2 Hepatic glycogen metabolic disorders The liver is essential for maintaining blood glucose homeostasis through the storage and release of glycogen to regulate blood sugar levels (Zhang et al., 2022a)