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Jiani Zhang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

A family of 200 structures was generated, and 20 structures with the lowest energies were selected for the final analysis

Risk factors for anaphylactoid reactions include higher infusion rates, a history of atopy or asthma, and female sex, which has been associated with a slightly increased likelihood of adverse reactions