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[22] Benvenga S, Feldt-Rasmussen U, Bonofiglio D, et al

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[] In the distal ileum and colon, gut bacterial bile salt hydrolase deconjugates the conjugated bile acids to CA and CDCA, and subsequently, the bacterial 7-dehydroxylase removes 7-hydroxyl group to convert CA and CDCA to secondary bile acids deoxycholic acid and lithocholic acid, respectively, followed by passive absorption or excretion into feces

These findings underscore that JAKSTAT3 signaling broadly regulates astrocytic reactivity across contexts, highlighting the need for refined biomarkers to distinguish adaptive from maladaptive states 140