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The common up-regulated genes include SLC2A6 , encoding a facilitated transporter that can also transport glucose, TDO2 , encoding tryptophan 2,3-dioxygenase which, like indoleamine 2,3 dioxygenase (IDO), catalyzes the first step in the degradation of tryptophan, CYBB ( NOX2 ), encoding gp91, the major subunit of phagosomal NADPH oxidase, and FTH1 (encoding ferritin heavy chain) which oxidizes Fe(II) to Fe (III)

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