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Elderly humans, for instance, exhibit 94.6% lower glutathione levels and significantly reduced synthesis rates compared to younger adults

GC production and secretion are tightly regulated by feedback mechanisms, primarily mediated by cortisol binding to glucocorticoid receptors (GR) and mineralocorticoid receptors (MR), which initiate negative feedback inhibition at multiple levels of the central nervous system and the HPA axis (Watzka et al., 2000)

Future studies may clarify optimal dosing strategies and identify populations that benefit most from bicarbonate-based hydration protocols

as mediated by complement (CDC) or by effector cells (ADCC)