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Administration of radio-labeled proteins, such as insulin-like growth factor-1 (IGF-1) and interferon-beta 1b (IFN-1b), into the rat nose leads to their distribution along trigeminal and olfactory nerve associated pathways and dissemination into both rostral and caudal regions of the rat brain within 3060 min, thus providing evidence of rapid brain access of CNS acting drugs through intranasal delivery [32, 33]

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Chronotype and sleep quality in obesity: how do they change after menopause