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Neurophysiological findings supported these behavioral results, with EEG data showing modulation of cortical activity related to pain processing

Knockout of Slc1A1 does result in cumulative neurodegeneration in the cortex (Aoyama et al., 2006), but it is unclear that a more modest reduction in expression, such as that seen by Wendland and colleagues (Wendland et al., 2009), would have a similar effect