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KIR3DL1 interaction with HLA-B27 is altered by ankylosing spondylitis associated ERAP1 and enhanced by MHC class I cross-linking

Moreover, ROS induced by copper and iron can cause DNA double-strand breaks, cell cycle arrest, mitochondrial dysfunction, lipid peroxidation and protein modification, which may ultimately mediate diverse types of cell death [29,30,31] (Table 1)