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The SigR-RsrA system of Streptomyces coelicolor and the Spx systems of Bacillus subtilis and Staphylococcus aureus have been most closely studied (Kang et al., 1999

[DOI] [PubMed] [Google Scholar] 53.Hurot J.M., Cucherat M., Haugh M., Fouque D

Consequently, the American Gastroenterological Association recommends that the patients with NAFLD engage in regular physical activity, aiming for 150300 min of moderate-intensity aerobic exercise (36 MET) or 75150 min of vigorous-intensity aerobic exercise (greater than 6 MET) per week [187]

However, the pleiotropic characteristic of cytokines and the widespread presence of cytokine receptors in various tissues lead to systemic toxicity if cytokines are delivered systemically, so in situ delivery of cytokines to tumors is necessary