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J., Muoz, J

Discovery of bisubstrate inhibitors of nicotinamide N -methyltransferase (NNMT)

NNMT knockdown significantly decreased glucose consumption and the expression of glycolysis-related enzymes, including HK2, LDHA, and PAGM1, thereby increasing the 5-FU sensitivity of EC1 cells ( PGAM1 upregulated 3-phosphoglycerate (3-PG) and 2-PG levels, inhibiting aerobic glycolysis (86)

From energy production to skin health, riboflavin plays a vital role in our well-being, demonstrating that the nutrients we consume have a profound impact on our bodily functions