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In their reporting on a 2025 study from the Journal of the American College of Cardiology (JACC), Medscape summed up, Compared with people who said they did not use cannabis, those who reported using the drug had a sixfold increased risk for heart attack, a fourfold increased risk for ischemic stroke, double the risk for heart failure, and three times the risk for cardiovascular death, heart attack, or stroke [10]

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adults, people were asked about smoking and their experience with six socioeconomic or health-related disadvantages: unemployment, poverty, low education, disability, serious psychological distress and heavy drinking

The effects of cholinergic and dopaminergic antagonists on nicotine-induced cerebral neurotransmitter changes