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Conventional and neo-antigenic peptides presented by beta cells are targeted by circulating naive CD8+ T cells in type 1 diabetic and healthy donors

Collectively, pentanoate exemplifies how microbial metabolites can bridge metabolic and epigenetic regulation to enhance cellular immunotherapyoffering a actionable, mechanism-driven adjuvant strategy that aligns preclinical mechanistic insights with clinical outcomes

For male reproduction, these chemotherapy drugs cause damage to male reproductive function in different degrees, such as testicular toxicity (decreased testicular weight, sperm count, plasma T and testicular histopathological changes) and genetic toxicity (chromosomal aberrations)

Eryptosis and aging Multicellular organisms are subject to the biological process of aging, and recently 12 different hallmarks of aging have been defined: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, dysregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis [415]