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Other studies suggest that oxidative damagethrough excessive reactive oxygen species (ROS)leads to metabolic disturbances in neurons and is closely associated with A accumulation, creating a vicious cycle (61)

For some individuals, results show up quicker as early as two weeks for some of the others it is not as quick

Oxidative stress In -thalassemia, ineffective erythropoiesis results in increased hemolysis and the release of free hemoglobin, which further exacerbates oxidative stress through the Fenton reaction, where iron catalyzes the conversion of hydrogen peroxide into highly reactive hydroxyl radicals (76)

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