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Acknowledgments We would like to thank Chettinad Academy of Research and Education, Chettinad Hospital and Research Institute for providing the facilities and agreed to provide article processing charge for open access publication and University Grants Commission (UGC) for providing financial support through Savitribai Jyotirao Phule Fellowship to the author Shruthi

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In all experiments, age-matched mice were used (unless otherwise stated), WT littermates served as controls, and treatment was randomly assigned to control for cage effect

If considering use beyond this period, particularly at doses providing more than 25 mg of elemental zinc daily, clinical review is advisable and monitoring for copper status may be appropriate in long-term use