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In the next experiment, buthionine sulfoximine (BSO, 10mM), the inhibitor of gammaglutamylcysteine synthetase was added during 24 hours to A549 cell culture (Figure 4)

Despite the transformative potential of DHTs, their effective implementation requires alignment with the specific clinical contexts and needs of each disease

C., Bordin, B

Further, PEGylated LNPs that efficiently encapsulate siRNA can be used against SNCA as they are shown to efficiently penetrate the BBB (Figure 4) and sustain gene knockdown in dopaminergic neurons