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Wahlgren, C

5.1.3 mGluR4 and immune cells The activation of mGluR4 can regulate the Th17 immune response

As key components of the innate immune system, macrophages exhibit typical SASP characteristics during ageing, with upregulation of proinflammatory cytokines (such as TNF-, IL-6, and IL-1) and downregulation of the anti-inflammatory cytokine IL-10 [150]