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(B&C) Confidently identified protein identifiers from the soluble and insoluble fractions were segregated into up regulated (B) or down regulated (C) based on 2-fold or greater abundances changes and submitted to DAVID for KEGG pathway analysis

Neurology 99, e1402e1413

This represents a second paradigm shift: moving beyond single-function delivery vehicles toward integrated platforms that combine multiple therapeutic modalities to actively reprogram the dynamic equilibrium between tumors and the immune system, essentially functioning as integrated immunomodulatory regulators. To systematically organize and clearly present the research advances covered in this review, Table 2 summarizes representative CpG-based nanoplatforms reported in recent years

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