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Meanwhile, HT significantly increased soluble protein content, proline and malondialdehyde (MDA) content as well as O 2 production rate, the gene expression and activities of antioxidant enzymes

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Apart from local inflammation, activation of glial cells (satellite glial cells, Schwann cells and immune cells) in the DRGs are also involved in the augmented inflammatory responses and enhanced neuronal excitability resulting in the development of pain hypersensitivity after chemotherapy treatment (Fumagalli et al., 2020)