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As a mitigation strategy, if the test for period effect post unblinding was significant, then the statistical model for the primary outcome had to be recomputed only on the data from the first period of the trial (where period effect is taken out)as recommended by clinical practice (3537)

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Among the diverse array of contaminants, organic pollutantssuch as industrial dyes, pharmaceutical waste, contaminants of emerging concern (CECs), and harmful biological agentspose severe risks to ecosystems and human health 11,25

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