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The agonist binding cavity in most bitter GPCRs is located deep within their transmembrane domain (TMD), with the exception of TAS2R7 in which it resides on the extracellular surface (Liu et al., 2018)

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Carbohydr Polym 106:335342 Editor information Editors and Affiliations Rights and permissions Copyright information 2025 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd