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Once toxicant burden is identified, the clinical roadmap shifts toward detoxification and immune modulation

The secondary antibody used was horseradish peroxidase (HRP)-conjugated anti-rabbit IgG (1:5,000 dilution

Notably, hepatocytes within assembloids exhibited higher expression of periportal markers, including SAA1 , SAA2 , HAMP and APOA1 , whereas pericentral genes such as CYP2E1 , CYP3A4 and GLUL were downregulated relative to h-HepOrgs cultured alone (Fig

This polysaccharide also activates the NF-B signaling pathway within cells, upregulating the activity of antioxidant enzymes and enhancing cellular antioxidant capacity ( Polysaccharides demonstrate the most significant efficacy in alleviating radiation-induced bone marrow suppression and immune exhaustion