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Table 1 Main indications and administration routes for B 12 treatment Evidence from animal and human studies shows that B 12 also has neuroprotective and anti-inflammatory properties,15 and intervention studies in humans have reported beneficial effects of better B 12 status or B 12 therapy in multiple sclerosis,16 Parkinsons disease,17 myalgic encephalomyelitis,18 autism,19 and (administering very high doses of methylcobalamin) in amyotrophic lateral sclerosis.20 Subcutaneous administration is sometimes recommended when intramuscular injections are contraindicated, for instance, in people using anticoagulants

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Cai T, Wagenlehner FM, Mazzoli S, et al

Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum