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The treatment with RSL3 (GPX4i) revealed a marked increase in ferroptotic sensitivity in CSFmax compared to Plasmax, an eaect that was rescued by the ferroptosis inhibitor Ferrostatin-1 ( Figure 3F , Sup

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These findings, along with the broad suppressive effects of Phe, Met, and Leu, align with the emerging role of single amino acid utilization by different bacterial species and strains in colonization, host range, and virulence (35, 38, 46, 56, 57)

Peptides and small molecules usually require different analytical methods, impurity assessments, formulation studies and stability programmes