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Stroke models showed that 1 mg/kg erinacine A administered to rats increased cell survival and reduced infarct volume after cerebral ischemia [8]

Production of precursor B lymphocytes in the bone marrow and the number of pro-B and pre-B lymphocytes decreased in aged mice and human [104]

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Collectively, these findings point to a coordinated mitochondrialnuclear epigenetic axis that is particularly critical during the maternal-to-embryo transition and has direct implications for reproductive aging and maternally inherited mitochondrial disease