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IGF-1 LR3's insulin-mimetic pathway bypasses pancreatic feedback, meaning your body won't secrete glucagon to raise blood glucose naturally

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Science (NY) 305:390392 Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

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