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Moreover, the dynamic communication of L-Phe at its predicted binding site in the hinge region with the Ca 2+ binding sites not only influences the adjacent Ca 2+ binding site 1, but also globally enhances cooperative activation of the receptor in response to alterations in extracellular Ca 2+

Tanimura Y, Aoi W, Mizushima K, Higashimura Y, Naito Y (2019) Combined treatment of dipeptidyl peptidase-4 inhibitor and exercise training improves lipid profile in KK/Ta mice