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Alprazolam orally disintegrating tablets are contraindicated in patients treated with potent CYP3A4 inhibitors (e.g., ketoconazole and itraconazole), because these medications significantly impair the oxidative metabolism mediated by cytochrome P450 3A (CYP3A) and can increase alprazolam exposures [see Clinical Pharmacology (12.3), Warnings and Precautions (5.9), and Drug Interactions (7.4)]

Variations in outcome for advanced gastric cancer between Japanese and Western patients: a subgroup analysis of the RAINBOW trial

This approach supports more realistic modelling of complex tissue environments

Regular consumption has been associated with reduced incidence of cardiovascular disease, T2DM, and several cancers, largely attributed to their effects on oxidative stress, lipid metabolism, and gut microbiota modulation